Perimenopausal women have both shorter and longer intermenstrual intervals, and irregular bleeding is common. In patients with Paget’s disease, risedronate directly decreases bone resorption, resulting in a significant decrease in serum alkaline phosphatase and urinary markers of bone collagen degradation. Hepatitis B may become active or get worse after you stop using adefovir Steady-state levels after multiple dosing are typically reached within 7 to 14 days for CMI.